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Can You Take Amitriptyline with CBD Oil?

Key Takeaways

  • Amitriptyline is a prescription antidepressant with a number of uses.
  • Only use CBD oil after seeking advice from your Doctor or healthcare professional.
  • Use CBD oil carefully with amitriptyline as it may increase its blood levels slightly.
  • Never abuse CBD or exceed the recommended dosage when using along with amitriptyline.

Many people are looking for alternative remedies like CBD oil to alleviate pain and suffering. However, when incorporating CBD into their wellness routine, questions may arise regarding its compatibility with prescription medications such as amitriptyline. This article explores the interaction between CBD oil and amitriptyline, shedding light on safety considerations and potential benefits.

Amitriptyline is quite an old drug, and we doctors still prescribe it for some health conditions. So, here I will tell you everything people need to know about using amitriptyline and CBD oil.

Understanding Amitriptyline and CBD Oil: Exploring Compatibility

Amitriptyline, a tricyclic antidepressant, is commonly prescribed to manage conditions such as depression, anxiety disorders, and chronic pain. It works by increasing the levels of certain neurotransmitters in the brain, thereby improving mood and reducing pain perception.

CBD oil has gained popularity for its health benefits, including pain relief, anxiety reduction, and anti-inflammatory properties. However, it’s essential to recognise that CBD can interact with certain medications due to its influence on metabolic enzymes in the liver.

Can I Take CBD Oil with Amitriptyline? Understanding the Risks

When considering the combination of CBD oil and amitriptyline, it’s crucial to consult with a healthcare professional. Not all medicines are safe to use with CBD. While research on the specific interaction between these two substances is limited, anecdotal evidence and preliminary studies suggest that CBD may affect the metabolism of certain medications, including amitriptyline.

Both CBD and amitriptyline are metabolized by the cytochrome P450 enzyme system in the liver. CBD has been shown to inhibit the activity of these enzymes, potentially affecting the metabolism and clearance of drugs like amitriptyline from the body. As a result, using CBD oil and amitriptyline together may lead to elevated levels of amitriptyline in the bloodstream, increasing the risk of side effects.(1)

Given the potential for interactions between CBD oil and amitriptyline, individuals should exercise caution when combining these substances. It is advisable to consult with a healthcare provider before initiating CBD supplementation, especially for those currently taking prescription medications like amitriptyline.

Exploring the Benefits of CBD Oil for Pain Management

Despite potential interactions with certain medications, CBD oil holds promise as a natural remedy for pain relief. Many individuals turn to CBD for its analgesic properties, seeking relief from conditions such as chronic pain, migraines, and neuropathic pain. So, think of using CBD for pain relief.

Research suggests that CBD may modulate pain perception by interacting with the body’s endocannabinoid system, which regulates pain sensation and inflammation. By targeting cannabinoid receptors in the central nervous system and peripheral tissues, CBD may help alleviate discomfort and improve overall quality of life.

Since here we are exploring using CBD with amitriptyline, it is worth noticing that doctors often prescribe this medication for nerve pains. So, people ask, “Can CBD oil help with nerve pain?” The answer is yes. It can help with or without amitriptyline. Of course, it is a helpful tool, not a treatment.(2)

Similarly, one may also explore the benefits of CBD oil for migraines. CBD is good for reducing pain sensation and aborting migraine attacks, and its consistent use may also help prevent migraine attacks.

The Bottom Line

CBD might not be a potent pain killer, but it is a good choice for chronic pain conditions, as it is one of the safest ways to manage pain in the long run.

How to use CBD oil for pain? Well, that is pretty simple: just take a few drops of CBD oil below the tongue a day. Do not forget to hold it below the tongue for a minute before swallowing, as this may result in greater pain relief.

However, if you are among those who do not like CBD oil, then CBD vape pens are just another option. It is quite a safe way of enjoying CBD health benefits. Of course, if you do not vape or smoke, then you better not get started, as vapes still cause side effects in some rare instances.


  1. Balachandran P, Elsohly M, Hill KP. Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review. J Gen Intern Med. 2021 Jul;36(7):2074–84.
  2. Australia H. Nerve pain (neuralgia) [Internet]. Healthdirect Australia; 2023 [cited 2024 Mar 27]. Available from:
Dr Preet Pal Singh Bhinder

This article was authored by: Dr. Preet Pal Singh Bhinder.

This article was peer-reviewed by Dr M Mansoor Siddique (PhD). Dr Siddique has over eight years of experience working with CBD and CBD products.

Disclaimer: All of our products are not intended to diagnose, treat or cure any disease. It is recommended to check with doctor before starting a new dietary supplement program. All CBD products sold have less than 0.2% THC content and abide by both EU an UK law.



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